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Nouvelle Publication #SUAL dans Journal of Viral Hepatitis

Publication, dans le journal scientifique de référence JHV, d'une étude Cas-Témoin réalisée à l'hôpital du Vinatier, sur le profil des personnes avec charge virale positive au VHC, par comparaison avec les patients séropositifs au VHC à charge virale négative. Une collaboration entre le CH Le Vinatier et le CRC de la Croix-Rousse.


 


­Coralie Torres 1, Guillaume Bauer 1, Sabrina Aubriet 1, Caroline Scholtes 2,3, ­François Bailly 3,4, ­Marianne Maynard-Muet 5, Pierre Pradat 5, Françoise Pillot-Meunier 1, Louis-Ferdinand Lespine 6, Benjamin Rolland 1,7,*

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Affiliations

1. Department of General Medicine in Psychiatry, MOPHA, Le Vinatier Hospital, Bron, France

2. INSERM U1052-Cancer Research Center of Lyon (CRCL), 69008, Lyon, France

3. Department of Virology, Croix Rousse Hospital, Hospices Civils de Lyon, Lyon, France

4. Department of Hepatology, Croix Rousse Hospital, Hospices Civils de Lyon, Lyon, France

5. Center for Clinical Research (CRC), Croix Rousse Hospital, Hospices Civils de Lyon, Lyon, France

6. Division for Clinical Research and Innovation (DRCI), Le Vinatier Hospital, Bron, France

7. Academic Department of Addiction Medicine, Le Vinatier Hospital, Bron, France



Abstract

Hepatitis C Virus (HCV) is highly prevalent in people with mental disorders (PWMDs). However, in the international context of HCV elimination, no previous study has explored the features of seropositive PWMDs with vs. without a positive viral load (VL). We retrospectively retrieved all HCV serology results of patients hospitalized in 2019, 2020, and 2021 in the second-largest psychiatric hospital of France. Using the medical records of all patients found seropositive for HCV, the following data were collected: sex (male, female), age (in years), previous history of illicit drug use except cannabis (yes or no), and previous history of incarceration (yes or no). We conducted a case-control comparison of these variables between the PWMDs who had vs. did not have a positive VL, thus providing odds ratios and 95% confidence intervals (ORs [95%CI]). In a total of 13,276 inpatients, 2,540 (19.1%) underwent at least one HCV serology; 55 of them (2.16%) were found positive. A VL count was performed for 48 of them, finding 15 (31.3%) individuals with active HCV. Compared to those with a negative VL, these 15 individuals were less likely to have previous documented illicit drug use (OR=0.18; 95%CI [0.05-0.68]) and to have been previously incarcerated (OR= 0.23; 95%CI [0.06-0.99]); age and sex did not statistically differ. In the context of HCV elimination, PWMDs yet to be treated for HCV are more likely to be those with no identified risk factor for HCV, which supports a strategy of systematic screening for HCV among PWMDs.


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